Bio X4 Review: Do They Really Work

Bio X4, a probiotic

Do you know your body contains bacteria inside it? No, not the ones that spread diseases but those that benefit the body. Harmful bacterias cause diseases and infections and knock the body’s immune system off balance, while good bacterias help eradicate the harmful ones from the body.

The good bacteria inside our body are known as probiotics. They also help keep the body weight in check.

A complication in which too much body fat stays on the body is known as obesity. It is a grave and rapidly spreading concern. Obesity leads to cardiovascular problems at a tender age, reduced physical activity, and behavioral changes.

The condition is primarily caused due to an unhealthy diet, liquid calories, and lethargy or being an inactive person all day long.

In today’s world, obesity occurs from an early age. Statistically, at least 20% of all Americans between the ages of 2 to 19 years are overweight, and at least 31% of the adult population is the same. 

A combination of living and beneficial bacteria and yeast that can live freely inside the human body without causing damage is known as probiotics. These probiotics primarily reside in the gut but can also present in the mouth, vagina, urinary tract, skin, and lungs.

The most common bacterial probiotics are Lactobacillus and Bifidobacterium, while the most common yeast found in probiotics is Saccharomyces boulardii. These beneficial microbes help with conditions like diarrhea, constipation, inflammatory bowel disease, irritable bowel syndrome, yeast infections, urinary tract infections, gum disease, lactose intolerance, etc.

Among the highly acclaimed probiotics, Bio X4 is a probiotic supplement that, besides supplying essential microbes, may also aid in weight loss and enhance digestion and metabolism. Nucific, a company from California, was the one who created it.

The designer and creator of the Bio X4 were Dr. Amy Lee. She envisioned her discovery would aid weight loss if a person follows a healthy lifestyle. Due to the good results, there are ample good Bio X4 reviews online. The company recommends taking one capsule for every meal. 

What does a probiotic supplement do:

Among the many goodnesses that the probiotic delivers, a few company-claimed benefits that stand out are:

  • Reduces weight by controlling food cravings and suppressing the appetite.
  • It helps burn more fat by boosting the metabolism.
  • It helps enhance the digestion process of our body
  • It decreases the signs of gas and bloating.

Introduction to Bio X4 probiotic supplement:

In this article, we will learn what Bio X4 is, what ingredients go into it, how it works, the advantages and disadvantages of using it, and many other things.

The Company Behind The Mind-Boggling Discovery

One of the critical indicators of a good probiotic supplement is the company selling it. Luckily we are reviewing an outstanding and unique product from a well-known company, Nucific. The bio x4 reviews highly praise the company because despite being new to the market, they have launched a product with a good USP: weight loss. The company’s motto is to supply its customers with all-natural products to improve their lives.

Based in California, Better Business Bureau is the registrar of the company. There are some negative comments about the delivery speed and the product’s pricing. But the product does wonders and is hand-crafted by a certified professional with a good amount of knowledge in dealing with obesity. The name of the person is Dr. Amy Lee. 

According to the Bio X4 reviews, the company offers various other products besides the Bio X4. These other products include Deep cell activator, probiotic complex, slimming chocolates, Krill oil, bone broth, etc.

The Ingredients :

According to many Bio X4 reviews, like any other probiotic supplement, Bio X4 contains four essential ingredients – the probiotic blend, the digestive enzyme blend, the weight management blend, and the craving control blend. Let’s discuss all the ingredients in detail now.

Probiotic blend

Although not much research data is available on whether a probiotic blend can effectively reduce weight or not, there is a couple of essential microbes that may help do that. Most effectively, Lactobacillus rhamnosus and Bifidobacterium lactis may help in weight loss. In addition, various other strains like Lactobacillus fermentum, Lactobacillus amylovorus, and Lactobacillus gasseri are promising results when implementing probiotics to reduce weight.

One study revealed that after taking Lactobacillus gasseri for 12 weeks, the participants found a decrease in body weight, BMI, waist size, and hip circumference. The good bacteria reduced even the belly fat of 8.5% of people after consuming the good bacteria. Some studies say women tend to lose a significant amount of weight if they consume probiotics regularly for three months. Bio X4 reviews are good, and not many users question its efficacy.

Digestive Enzyme Blend

Enzymes are required to accelerate the human body’s chemical reactions. They are protein molecules. The enzymes present in the digestive system help break down food into smaller pieces known as nutrients, which the body can easily absorb. Bio X4 probiotic supplement contains three primary enzymes – Amylase, lipase, and bromelain.

  • The enzyme amylase helps break starch into simpler molecules. It yields maltose in the final stages. Saliva also contains amylase. It helps break carbohydrates in the food into glucose, which ultimately helps produce energy in our bodies. Pancreatic amylase helps in the proper digestion of food.
  • Lipase helps in breaking fat molecules into simpler substances. They have various vital roles in the digestive system, transportation, and processing of dietary lipids. The bile salt-dependent lipase in the pancreas helps in the faster digestion of fats, pancreatic lipase in the digestive juice aids in the breaking of fats, and hepatic lipase helps in the regeneration of LDL (Low-density lipoproteins), etc.
  • Bromelain is a proteolytic enzyme that helps fight pain and swelling in the human body. One can find it in pineapples. According to the USFDA, it is a dietary supplement. People also use the enzyme to treat muscle soreness, burns, etc. It also aids digestion, osteoarthritis, cardiovascular diseases like stroke, heart attack, high blood pressure, asthma, colitis, and some studies to prune the cancer cell growth.

The Weight Management Blend

Bio X4 uses Epigallocatechin-3-gallate (EGCG), which occurs naturally in green tea as an antioxidant and anti-inflammatory compound. It improves the fat-burning property of the human body and protects the body against cellular damage. Besides tea, one may find it in some fruits and nuts.

EGCG helps reduce inflammation, heart disease, diabetes, etc. In addition, the compound, when taken alongside caffeine, helps reduce weight. Studies show that intake of 100-460 mg of EGCG and 80-300 mg of caffeine for 12 weeks can result in weight loss. In addition, the extract helps improve heart and brain health and reduce stress.

The extract isn’t 100 % safe and has a few side effects attached to it. Some of these effects include dizziness, low blood sugar, and anemia. Many experts believe that the side effects may be because of the toxins in supplements, not EGCG. Pregnant women or lactating mothers should stay away from the extract or any product containing it because it might affect the child’s development. 

There have been instances when people found EGCG interfering with prescription drugs. Fortunately, many Bio X4 reviews say that the product has a negligible presence of the compound or the extract.

The Appetite Suppressing Blend

A popular extract that the probiotic supplements use is from Caralluma Fimbriata, an edible cactus growing abundantly in India. One can also find the plant in several parts of Africa, the Middle East, and Southern Europe (Canary Islands). The plant suppresses appetite, aiding in weight loss, building endurance, and suppressing thirst. Studies say people who use the plant extract for 12 weeks observe a reduction in weight without any adverse side effects.

According to Perspectives In Clinical Research, there is a requirement for more scientific data to show that the plant extract is anti-obesity. As per their survey, one couldn’t observe much difference in participants after 12 weeks, but the number of side effects also weren’t any.

According to Complementary Therapies in Medicine, C.fimbriata is the only plant among 14 studies plants capable of reducing hunger. The theory also concludes by saying when one adds the extract into a supplement, the results would be outstanding. In addition, if the plant extract can control obesity, the risks of certain cardiovascular diseases would cease. 

According to a report by the North American Journal of Medical Sciences, one could see a significant reduction in overeating in children. Thus, resulting in the control of obesity. The researchers tested for ten weeks with participants from Australia and New Zealand. 

From the above results, it isn’t wholly sure whether or not the plant extract can help in weight loss. Research is ongoing to find out the result.

How Does It Work :

There are layers of working of the Bio X4. First, let’s deal with the Probiotic supplement part. One should take the supplement in the early hours of the day, i.e., when one wakes up or after breakfast. The reason for this is in the morning; the stomach acids are at their lowest levels. Thus, the journey of the probiotic bacteria from the mouth to the gut won’t be much challenging.

The stomach acid also acts as a significant barrier against foreign antigens. Harmful microbes find the stomach’s acidic environment too tough to handle and thus perish. Thus, similarly, probiotic bacteria may also become victims of the same acidic environment. Thus, ingesting the supplement early in the morning would be beneficial, and according to the Bio X4 reviews, the strains of bacteria are robust enough to survive such harsh conditions.

The probiotic bacterias come into the small intestine. Some bacterias make their temporary shelters here, while others pass into the large intestine. Different bacterial strains will act differently due to different pH levels, oxygen levels, and acidity or basicity. For example, the Lactobacillus rhamnosus bacteria travels into the gut.

The bacteria adapts itself extensively to the acidic and basic conditions in the body and colonizes the intestinal walls, providing long-term benefits to the body. In addition, the bacteria break down lactose, forming lactic acid. The bifidobacterium lacti also live in the human GI tract and provide positive health effects.

By outnumbering the antigens, the probiotic bacteria steal the food and shelter from the antigens, thus rendering them helpless. The situation makes it harsh for harmful bacteria and microbes to survive inside the human body. Probiotics also produce various acids that prevent the further growth of those harmful microbes.

With the number of good and harmful bacteria decreasing, the person starts feeling positive changes in digestion and overall lifestyle. In addition, due to reduced toxin levels in the gut, the person feels more active and less susceptible to diseases. 

Digestive enzymes affect our body by breaking down foods into simpler substances and nutrients our body can absorb easily. For example, amylase breaks down starch into sugar or glucose. The process starts in the mouth where salivary amylase is present and goes on until the stomach.

If amylase isn’t present in the correct quantity, diarrhea may occur. Like the other enzyme, a lipase acts with liver bile to break down fats. If one lacks Vitamin A, D, B, and K, then there will be a good reason to doubt that the person lacks the proper quantity of lipase in the body. Other digestive enzymes break down other nutrients into smaller fractions.

The Pros And Cons Of Using Bio X4 :

Every drug comes with side effects, just like the benefits. Every probiotic supplement also comes with both benefits and risks. Let’s study the advantages and disadvantages of using bio x4.

The Pros :

Organic approach

The world is moving towards organic and plant-based medicine because of the adverse health impacts of synthetic drugs. These drugs are all-natural and have sound effects on the body. According to the company website and several bio x4 reviews, the components used in Bio X4 are organic. Starting from the probiotic bacterias to using EGCG and enzymes driven from plants.

Taking an organic approach makes the supplement more affordable than its synthetic counterparts. It also makes them easier to purchase, helps in natural healing, provides strength to not one part of the body but to the whole body, has several side effects, and is economical for both the consumer and the company.

Assists Weight Loss

One of the unique selling propositions of Bio X4 is besides doing good to the overall body, it will cut down weight too. Obesity and gaining unnecessary weight is a huge problem in children and young adults of the 21st Century. The USA is a country that ranks high in terms of the population suffering from obesity.

Appetite suppressing extracts from the Caralluma Fimbriata plant, probiotic bacteria Lactobacillus gasseri, and EGCG are showing promising results, according to Bio X4 reviews. These three things help in weight loss, and studies show regular use shows outstanding results within 12 weeks. Unfortunately, few probiotic manufacturers focus on this front, which Nucific has captured successfully.

It has many other benefits.

There are various health benefits of introducing probiotic supplements into one’s body. Some of the benefits, according to the Bio X4 reviews, that Bio X4 helps one with are:

  • They help in better digestion. Probiotic supplements check an imbalance in the digestive tract due to illness or foreign antigens. To eradicate those antigens, Bio X4 works best.
  • Do you know the common symptom of consuming antibiotics? It’s diarrhea. Research shows that at least 42% of users of probiotic supplements like Bio X4 felt relieved from diarrhea. It may also reduce Traveller’s diarrhea by 8% and diarrhea in children by more than 50%.
  • Besides physically taking care of our bodies, these supplements also take care of our mental health. Bifidobacterium and Lactobacillus can help improve anxiety, depression, and stress conditions after using the supplements for one to two months.
  • Probiotic supplements help lower LDL or bad cholesterol in the body. Various lactic acid-producing bacterias reduce cholesterol. These bacteria break down the bile inside the gut, where they reside inside the human body, preventing the cholesterol from forming. People with high blood pressure may find comfort after consuming Bio X4, a probiotic supplement.
  • It may reduce the symptoms of digestive disorders.
  • Various Bifidobacterium and Lactobacillus species may help a person with ulcerative colitis and Chron’s disease. But the amount of data on whether or not probiotics can help with Chron’s disease is debatable, but results are there in the case of the condition. In addition, these supplements help with bowel disorders and may eliminate irritable bowel syndrome (IBS).
  • Thus, we can see that probiotics help the digestive system but also help build the immunity system. They help in the production of IgA-producing cells, T-lymphocytes, etc. Probiotic supplements like Bio X4 help young children with respiratory diseases and reduce respiratory infections. Studies have also observed these probiotics reduce Urinary Tract Infection (UTI) in women.

It is gluten-free

Gluten is a type of protein which you can find in wheat products. Many people find it difficult to digest. Celiac disease is when the body attacks itself on coming in touch with gluten. It is an autoimmune disease. Often people avoid gluten because of constipation, stomach pain, bloating, skin rashes, allergies, etc. Less consumption or no consumption of gluten helps boost energy and lose weight. In addition, people get relieved of digestive problems like bloating, gas formation, constipation, fatigue, pain, etc.

It aids in sound sleep

Insomnia is when a person can’t sleep despite trying to do so at the correct time. The condition leads to increased irritability, lack of energy, motivation to work, extreme dullness and laziness, stress, depression, etc. It requires immediate medical assistance.

As we have already said, Probiotic supplements like Bio X4 help reduce several mental conditions. First, it helps reduce stress, one of the biggest reasons why insomnia and sleeplessness happen in humans. Second, probiotic supplements promote a calm mind by reducing stress; a relaxed mind can sleep better than a cluttered mind.

The Cons :


In the modern world, with the advent of the internet, every consumer wants their product available in both offline and online marketplaces. When a brand visualizes a product to go strong in the market and generate good sales orders, it should position the product strategically both online and in physical stores. Nucific didn’t do that because the Bio X4 is only available online. They have no presence in the retail outlets where every probiotic seller should be. By not being physically present, the company is losing out on many potential old-age customers who don’t know about internet use. 

Side effects

Many people have said to face allergic reactions after using the product. Bio X4 reviews say that certain types of bacteria may produce histamine, so if one is intolerant to histamine, one may have problems with the probiotic supplement.

In addition, minor side effects like constipation, nausea, bloating, or other gastrointestinal problems may arise due to Caralluma Fimbriata. The EGCG inside the product may promote dizziness, lower blood sugar, and kidney problems, but the meager amount of the extract won’t produce many side effects in the user’s body.

Apart from flatulence and mild bloating, people with pre-existing conditions could face medical problems like short bowel syndrome, or maybe the immune system gets compromised. 

Overblown advantages

The product claims too many benefits without the proper research behind it. In addition, some of the claims require more scientific details. 

Dosage :

Regular three capsules of Bio X4 is what the company recommends. One can take a pill before each meal – breakfast, lunch, and dinner. Those who don’t wish to consume three may stick to two but having one at an early hour or once after getting up from bed in the morning would be highly impactful. To avoid complications, avoid taking pills beyond six.

To improve digestion, consume the capsule with clear water before the meal. One shouldn’t keep unrealistic expectations that within a few days, one will see results or one may get wholly cured of some complication. The company doesn’t guarantee a cure for any disease but heavily campaigns about the weight loss feature. Bio X4 reviews suggest that weight loss is there in multiple people precisely due to the weight loss-focussed ingredients used in the product.

People Who Shouldn’t Consume It

Several people are lactose-intolerant and gluten-intolerant. According to other Bio X4 reviews, the company has made Bio X4 completely lactose and gluten-free for people like these. However, there will still be certain sections of society who shouldn’t intake the product. Some of them include:

  • If a woman is pregnant or lactating, one must seek a doctor’s advice before ingesting any supplements. There is no pertinent information regarding the safety of women bearing a child or breastfeeding mothers. Certain constituents of the supplement may affect the development of the child. A mother should never compromise on the health of her child. Thus, it is never advisable to intake any supplement product when pregnant or breastfeeding.
  • Children below 18 years of age may develop unwanted side effects from consuming the supplement. People in their mid-teens are generally reckless and want everything fast. Thus, if someone of that age trying to get slim, intakes the product, and wants fast results, overdoses on the product, the company won’t be liable. 
  • People with already existing conditions or a compromised immune system should avoid the Bio X4 because it affects several essential bodily functions like appetite stimulation, weight reduction, etc. These effects might take a toll on the body of an already diseased human. Thus, these people shouldn’t consume probiotic supplements.
  • People who have unrealistic expectations should stay away from the supplement. It won’t give a person fast results. One has to wait at least two months before early results start to show up. Thus, for people who want to get slim within a month or want a cure for a disease, Bio X4 isn’t for them.

FAQs :

What are the possible effects of the consumption of Caralluma Fimbriata?

Besides changes in appetite, the plant extract may also have a few side effects. These effects include stomach pain, nausea, formation of gas, etc. However, these symptoms ease up in a day or two, but if the problem persists, one must seek medical assistance.

What is the dosage of Bio X4?

The company recommends intaking three capsules each day—one after every meal – breakfast, lunch, and dinner. One may also consume two if three seems a big deal. We recommend prior consultation with a doctor.

Can one lose weight using Bio X4?

The company’s ingredients used to manufacture the probiotic supplement may aid in weight loss, but there is no solid scientific proof that it can do so. Ongoing research will open new doors. The time taken to show results varies from person to person. Thus, one must give time to the product and the ingredients to show results.

Is it safe to consume Bio X4?

Bio X4, a probiotic supplement, is an approved product by the FDA. The product uses all legal ingredients, and the FDA permits each. Thus, considering some side effects, it is safe to consume Bio X4.

How long does it take for the product to show results?

On average, people get to see some results after 12 weeks. However, most people see results from the product’s active ingredients between 60 and 90 days from the date of the first intake, given that one consumes the product regularly, at least two capsules.

Where can I purchase Bio X4?

One can purchase the Bio X4 product from the Nucific official website.

What is the warranty of Bio X4?

The 90-day money-back guarantee is a unique thing to deliver to the customers.

What are the key benefits of Bio X4?

The best benefits that one can get from Bio X4 are an optimized digestive system, appetite reduction, weight loss, gut health immunity booster, and enhanced metabolism.

Is Bio X4 a genuine product?

It is one of the most reputed products of Nucific. Thus, they won’t compromise the legitimacy of their hero product. There is no doubt that the product is legal, genuine, and safe for consumption.

Conclusion :

When choosing the best probiotic supplement, we would say one must check the effective dosage, the ingredients, and the personal needs. A registered physician must review and register the brand selling the probiotic, and the product should follow the rules and regulations of the FDA.

It should follow the modern manufacturing practices as said by the FDA. Finally, the company that manufactures the product must be trustworthy and should have ample good reviews to support its claims.

Most modern probiotic supplements are dairy and gluten-free. Check what supplements benefit the most. The product should be travel-friendly, relatively affordable, suitable for all ages, and most importantly, lab-check. There should be a third-party lab check because an in-house lab check may provide fraudulent details about the product. The Bio X4 is the one we recommend with all the above checks, and it has few side effects and works like a charm in the body.

One can find biogenic amines in foods containing high proportions of probiotics—for example – yogurt and kimchi. However, protein fermentation is one of the most common sources of biogenic amines. Tyramine, Histamine, Phenylethylamine, and Tryptamine could be a few examples of amines inside protein-rich foods.

It relieves most digestion problems and complications, helps mental well-being, improves metabolism, and helps lose weight. With the several features, the price might seem a bit on the higher side. There have been complaints regarding this to the company. We are sure they have listened to the complaints and will work on them accordingly. Another problem is tall claims.

The company should claim only things that can proven and not give its consumers false hopes. Having done such a great job within such a short time, Bio X4 is an outstanding probiotic supplement and is here to stay in the market for a long time. With this, we conclude our comprehensive Bio X4 review.

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